Abstract Polytrauma syndrome, particularly among military veterans and individuals with traumatic brain injury (TBI), is associated with complex neuropsychiatric, metabolic, and neuroendocrine dysfunction. Conventional treatment approaches often focus on isolated symptoms rather than underlying systems-level dysregulation. This paper proposes a comprehensive integrative clinical protocol addressing neuro-metabolic dysfunction, neuroendocrine abnormalities, and cerebral hypometabolism in patients with polytrauma syndrome. The approach integrates hormonal assessment and optimization, metabolic support, and low-pressure hyperbaric oxygen therapy (HBOT). This framework is presented as a hypothesis-generating model aimed at improving outcomes in a population with persistently high morbidity and mortality
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